Emerging Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Chronic Respiratory Diseases: An Overview of Recent Progress

Emerging Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Chronic Respiratory Diseases: An Overview of Recent Progress

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Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are able to carry genetic and protein goods to mediate the interaction between MSCs and target cells.Recently, more and more researches have focused on the therapeutic role of MSC-EVs in chronic respiratory diseases.In this review, we summarize the cumulative strategies and mechanisms of MSC-EVs in treating chronic respiratory diseases.

This review suggests that MSC-EVs may serve as a novel cell-free-based therapy Ball - Catcher - Helmets for chronic respiratory diseases, including COPD, asthma, pulmonary fibrosis, and pulmonary arterial hypertension.In current studies of chronic respiratory diseases, umbilical cord and bone marrow are main sources of MSC-EVs, while adipose tissue, lung, and induced pluripotent stem cells are also applied.Isolation methods of MSC-EVs in treating chronic respiratory diseases involve ultracentrifugation, exosome extraction kits and anion-exchange chromatography.

Intratracheal delivery and intravenous administration are Sports Bra the most widely used routes of MSC-EVs.MSC-EVs are able to transfer microRNAs and protein to target cells and further magnify the therapeutic effects.